In 1977 Humberto graduated from the University of São Paulo with a degree in law and starts practising as a lawyer. In 1984 Fernando completed an architectural degree at the Art College of São Paulo and joined Humberto, who had given up law to become a sculptor. Together they experimented with designing and making metal furniture.
Ordinary materials are transformed and reinvented into priceless objects that carry both creativity and the spirit of Brazil – a combination of chaos and solution. The Campana Brothers are constantly investigating new design possibilities.
They started in 1989 with a furniture exhibition, provocatively called "The Inconsolable", a political manifesto rather than functional objects. The Campanas designed the "Casulo Shelf" (1989) and exhibited their furniture in commercial galleries in São Paulo and New York. In 1991 they created the "Favela Chair", made from scraps of wood found in a São Paulo slum. Humberto and Fernando designed the "Vermelha chair" and Card Board Collection (1993). In Italy they participated in the exhibition "Viaggio in Italia" at Abitare il tempo of Verona in 1994, and in 1995 in the exhibition organized at the Brazilian Consulate of Milan "Il Brasile fa anche design". In 1997 the Campanas exhibited in Milan and completed the design of the "Cone chair". The Italian lighting company O Luce produced their Estela Lamp. Some of their works are included in the International Design Year Book of 1997, edited by Philippe Starck. In 1998 together with the German lighting designer Ingo Maurer, the brothers presented the "Project 66" exhibition at the Museum of Modern Art (MoMA), New York. The Italian furniture manufacturer Edra started producing their furniture beginning with the cotton string "Vermelha chair".
Estudio Campana designs are part of the permanent collections of MoMA New York, the Centre Georges Pompidou in Paris, and the Vitra Design Museum in Weil am Rhein, Germany.
In 2008 Humberto and Fernando Campana received an award as "Designer of the year" at the Design Miami fair.