She attended the faculty of architecture of the Madrid Polytechnic and the Milan Politechnic where she graduated in 1989.
From 1990 to 1992 she was assistant lecturer to both Achille Castiglioni and Eugenio Bettinelli at the Milan Polytechnic and E.N.S.C.I. in Paris.
Between 1990 and 1996 Urquiola was responsible for the new product development office of DePadova and designed with Vico Magistretti the products "Flower", "Loom Sofa", and "Chaise Longue".
From 1993 to 1996 she had an associate practice with the architects de Renzio and Ramerino and was engaged in architectural design, showrooms, restaurants and franchising (Maska/Italy, Tomorrowland Stores/Japan, Des Pres/France).
In 1996 Urquiola became head of the Lissoni Associati design group working for Alessi, Antares-Flos, Artelano, Boffi, Cappellini, Cassina, Kartell, and others. Additionally, on her own, she created for such as B&B, Bosa, De Vecchi too, Fasem, Kartell, Liv’it, Molteni & C., Moroso and Tronconi and designed stands and showrooms for Knoll, Moroso, Sag 80, and Somma.
Her products were selected for the Italian Design 2001 exhibition and for the International Design Yearbook 1999 and 2001.
In 2001 she was chair of the jury for the 19th CDIM Design Award and was lecturer at the Domus Academy in Milan.
Also in 2001 Patricia Urquiola opened her own studio in Milan for design, exhibitions, art direction, and architecture. Her clients are companies as B&B Italia, Driade, Molteni, Moroso and Foscarini.